Hurricane Irma will “devastate” either Florida or neighbouring states, the head of the US federal emergency agency has said.
Brock Long said parts of Florida would be without power for days, and more than 100,000 people may need shelter.
Meanwhile there are reports of serious looting on the hurricane-hit Caribbean island of St Martin.
Hurricane Irma has left a trail of destruction in the Caribbean, affecting an estimated 1.2m people.
It has been downgraded to a category four storm, but officials warn that it remains “extremely dangerous”.
The US National Weather Service says that Irma was expected to bring wind speeds of around 165mph (270km/h) over the weekend.
Some 500,000 people were told to leave south Florida with Irma due on Sunday.
“Hurricane Irma continues to be a threat that is going to devastate the United States in either Florida or some of the southeastern states,” Fema administrator Mr Long said.