Kane travels to West Bromwich Albion on Saturday having scored 15 goals away from home this season, only one less than the highest tally in a single campaign.
That was set by Kevin Phillips who hit 16 on the road for Sunderland in 1999/00.
Four goals ahead of Kane's 27, Salah also has a chance of breaking the record in his final away match, at former club Chelsea on Sunday.
Thirteen of the Liverpool forward's 31 strikes this season have come away from home.
He would need a hat-trick to match Phillips's mark, and a repeat of March's four-goal haul against Watford to surpass it.